Development of transcriptionally regulated oncolytic adenoviruses

@article{Ko2005DevelopmentOT,
  title={Development of transcriptionally regulated oncolytic adenoviruses},
  author={Derek Ko and Lynda Hawkins and De-Chao Yu},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={7763-7774}
}
Changes initiated at the cellular and systemic levels as a result of viral infection or neoplastic transformation share significant overlap. Therefore, the use of replicating viruses to treat tumors has long been postulated as a promising avenue for oncolytic therapy. Over the last 10 years, transcriptionally regulated adenoviruses have become a popular platform for the development of such oncolytic viruses. Placement of heterologous promoters in front of key adenoviral transcription units to… CONTINUE READING

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