Development of tolerance to the anticonvulsant effect of vigabatrin in amygdala-kindled rats.

@article{Rundfeldt1992DevelopmentOT,
  title={Development of tolerance to the anticonvulsant effect of vigabatrin in amygdala-kindled rats.},
  author={Chris Rundfeldt and Wolfgang L{\"o}scher},
  journal={European journal of pharmacology},
  year={1992},
  volume={213 3},
  pages={
          351-66
        }
}
The anticonvulsant, adverse and biochemical effects of the novel antiepileptic drug vigabatrin (gamma-vinyl GABA), which increases GABA (gamma-aminobutyric acid) levels by inhibition of the GABA degrading enzyme GABA aminotransferase, were examined in amygdala-kindled rats after acute and chronic administration. Vigabatrin proved to be a potent anticonvulsant drug at acute doses (100-200 mg/kg), but during chronic administration, the anticonvulsant activity of the treatment was lost already in… CONTINUE READING
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