Development of thymic NK cells from double negative 1 thymocyte precursors.

  title={Development of thymic NK cells from double negative 1 thymocyte precursors.},
  author={Claudia L Vargas and Jennifer Poursine-Laurent and Liping Wu Yang and Wayne M Yokoyama},
  volume={118 13},
The differentiation of natural killer (NK) cells and a subpopulation of NK cells which requires an intact thymus, that is, thymic NK cells, is poorly understood. Previous in vitro studies indicate that double negative (CD4⁻CD8⁻, DN) thymocytes can develop into cells with NK cell markers, but these cells have not been well characterized. Herein, we generated and characterized NK cells differentiating from thymic DN precursors. Sorted DN1 (CD44⁺CD25⁻) CD122⁻NK1.1⁻ thymocytes from Rag1(⁻/⁻) mice… CONTINUE READING

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