Development of thiolated poly(acrylic acid) microparticles for the nasal administration of exenatide.


The purpose of this study was to develop a microparticulate formulation for nasal delivery of exenatide utilizing a thiolated polymer. Poly(acrylic acid)-cysteine (PAA-cys) and unmodified PAA microparticles loaded with exenatide were prepared via coprecipitation of the drug and the polymer followed by micronization. Particle size, drug load and release of… (More)
DOI: 10.3109/03639045.2013.842578


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