Development of thermostable Candida antarctica lipase B through novel in silico design of disulfide bridge.

@article{Le2012DevelopmentOT,
  title={Development of thermostable Candida antarctica lipase B through novel in silico design of disulfide bridge.},
  author={Quang Anh Tuan Le and Jeong Chan Joo and Y. J. Yoo and Yong Hwan Kim},
  journal={Biotechnology and bioengineering},
  year={2012},
  volume={109 4},
  pages={867-76}
}
Lipase B from Candida antarctica (CalB) is a versatile biocatalyst for various bioconversions. In this study, the thermostability of CalB was improved through the introduction of a new disulfide bridge. Analysis of the B-factors of residue pairs in CalB wild type (CalB-WT) followed by simple flexibility analysis of residues in CalB-WT and its designated mutants using FIRST server were newly proposed to enhance the selective power of two computational tools (MODIP and DbD v1.20) to predict the… CONTINUE READING

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