Development of therapeutic combinations targeting major cancer signaling pathways.

Abstract

Signaling networks play key homeostatic processes in living organisms but are commonly hijacked in oncogenesis. Prominent examples include genetically altered receptor tyrosine kinases and dysregulated intracellular signaling molecules. The discovery and development of targeted therapies against such oncogenic proteins has imparted clinical benefit… (More)
DOI: 10.1200/JCO.2011.37.6418

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Cite this paper

@article{Yap2013DevelopmentOT, title={Development of therapeutic combinations targeting major cancer signaling pathways.}, author={Timothy A Yap and Aurelius Gabriel Omlin and J de Bono}, journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology}, year={2013}, volume={31 12}, pages={1592-605} }