Development of the thymus requires signaling through the fibroblast growth factor receptor R2-IIIb.

@article{Revest2001DevelopmentOT,
  title={Development of the thymus requires signaling through the fibroblast growth factor receptor R2-IIIb.},
  author={J M Revest and Ravinder K. Suniara and Karol Kerr and J. J. Owen and Cole Dickson},
  journal={Journal of immunology},
  year={2001},
  volume={167 4},
  pages={1954-61}
}
Mice deficient for fibroblast growth factor (Fgf)R2-IIIb show a block in thymic growth after embryonic day 12.5, a stage that just precedes its detection in thymic epithelial cells. Fgf7 and Fgf10, the main ligands for FgfR2-IIIb, are expressed in the mesenchyme surrounding the thymic epithelial primordium, and Fgf10-deficient mice also exhibit impaired thymic growth. Hence, Fgf signaling is essential for thymic epithelial proliferation. In addition to the proliferative block, most thymic… CONTINUE READING