Development of the research on the application of chlorotoxin in imaging diagnostics and targeted therapies for tumors.

@article{Wu2010DevelopmentOT,
  title={Development of the research on the application of chlorotoxin in imaging diagnostics and targeted therapies for tumors.},
  author={Xiao-shan Wu and Xin-chun Jian and Bing-jiao Yin and Zhi-jing He},
  journal={Chinese journal of cancer},
  year={2010},
  volume={29 6},
  pages={
          626-30
        }
}
Precisely locating tumors always proves to be difficult. To find a molecule that can specifically bind to tumor cells is the key. Recently, chlorotoxin (CTX) has been proved to be able to bind to many kinds of tumor cells. The CTX receptor on the cell surface has been demonstrated to be matrix metalloproteinase-2 (MMP-2). Many researchers have combined CTX with other molecules, including 131I, Cy5.5, iron oxide nanoparticles coated by polyethylene glycol (NP-PEG), and so on, and thus… 
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24 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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24 Citations

Citation Type

Citation Type

Chlorotoxin—A Multimodal Imaging Platform for Targeting Glioma Tumors
TLDR
With its ability to penetrate the blood-brain-barrier and its tyrosine residue allows covalent conjugation with functional moieties, CTX is an attractive platform to explore development of diagnostic and therapeutic agents for gliomas.
Current Biochemical Applications and Future Prospects of Chlorotoxin in Cancer Diagnostics and Therapeutics
TLDR
The currently known applications of CTX are reviewed and diverse ways in which it can be applied for the design of improved drugs and diagnostic tools for cancer are suggested.
Recent advances in diagnosis and treatment of gliomas using chlorotoxin-based bioconjugates.
TLDR
A review on the important role of ion channels in the underlying mechanisms of gliomas invasive growth and how CTX suppressesgliomas proliferation and migration and the recent advances in the applications of CTX bioconjugates for glioma diagnosis and treatment are summarized.
Fabrication of doxorubicin and chlorotoxin-linked Eu-Gd2O3 nanorods with dual-model imaging and targeted therapy of brain tumor
Chlorotoxin-conjugated nanoparticles as potential glioma-targeted drugs
TLDR
Iron oxide, multifunctional superparamagnetic, and NaYF4:Yb,rare-earth upconversion nanoparticles, conjugated with chlorotoxin, exhibit high affinity for glioma and direct tumor visualization.
Polymalic acid chlorotoxin nanoconjugate for near-infrared fluorescence guided resection of glioblastoma multiforme.
Chlorotoxin: A Helpful Natural Scorpion Peptide to Diagnose Glioma and Fight Tumor Invasion
TLDR
Among all the chlorot toxin-based strategies, the most promising one to enhance patient mean survival time appears to be the use of chlorotoxin as a targeting agent for the delivery of anti-tumor agents.
Nonclinical Profile of BLZ-100, a Tumor-Targeting Fluorescent Imaging Agent
TLDR
The combined imaging, safety pharmacology, PK, and toxicology studies contributed to an extensive initial nonclinical profile for BLZ-100, supporting first-in-human clinical trials.
Chlorotoxin: Structure, activity, and potential uses in cancer therapy
TLDR
The structure, activity and potential applications of chlorotoxin as a drug design scaffold are reviewed and its interesting structural and biological properties are reviewed.
New opportunities and challenges of venom-based and bacteria-derived molecules for anticancer targeted therapy.
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References

SHOWING 1-10 OF 21 REFERENCES
In vivo MRI detection of gliomas by chlorotoxin-conjugated superparamagnetic nanoprobes.
TLDR
High targeting specificity and benign biological response establish this nanoprobe as a potential platform to aid in the diagnosis and treatment of gliomas and other tumors of neuroectodermal origin.
Targeted delivery of antitumoral therapy to glioma and other malignancies with synthetic chlorotoxin (TM-601)
TLDR
It is demonstrated that intracavitary dosing of 131I-TM-601 appears safe, minimally toxic, and binds malignant glioma with high affinity and for long durations, and that this peptide represents a potentially important targeting agent for many cancers.
Tumor paint: a chlorotoxin:Cy5.5 bioconjugate for intraoperative visualization of cancer foci.
TLDR
Mouse studies revealed that CTX:Cy5.5 has the potential to fundamentally improve intraoperative detection and resection of malignancies and has favorable biodistribution and toxicity profiles.
Specific targeting of brain tumors with an optical/magnetic resonance imaging nanoprobe across the blood-brain barrier.
TLDR
A nanoprobe is presented that shows an ability to cross the blood-brain barrier and specifically target brain tumors in a genetically engineered mouse model, as established through in vivo magnetic resonance and biophotonic imaging, and histologic and biodistribution analyses.
A ligand-mediated nanovector for targeted gene delivery and transfection in cancer cells.
Use of chlorotoxin for targeting of primary brain tumors.
TLDR
In the tumor-bearing severe combined immunodeficient mice, the vast majority of the brain-associated radioactivity was localized within the tumor, suggesting that CTX and CTX-conjugated molecules may serve as glioma-specific markers with diagnostic and therapeutic potential.
Chlorotoxin Inhibits Glioma Cell Invasion via Matrix Metalloproteinase-2*
TLDR
It is shown that the anti-invasive effect of Cltx on glioma cells can be explained by its interactions with MMP-2, and it is suggested that Cltx is a specific M MP-2 inhibitor with significant therapeutic potential for gliomas and other diseases that invoke the activity of Mmp-2.
Radiation dosimetry of 131I-chlorotoxin for targeted radiotherapy in glioma-bearing mice
TLDR
Dosimetry results of 131I-Chlorotoxin in athymic nude mice with intracranially implanted human glioma xenografts and projected radiation doses in patients receiving 370 MBq of 131i-Ch chlorotoxin demonstrated potential in improving patient survival using this novel targeting agent.
Imaging glioma extent with 131I-TM-601.
TLDR
131I-TM-601 provides a reliable estimate for primary tumor extent and further modification of this radiopeptide with other better imaging isotopes may provide an important tool for determining tumors extent and differentiating regions of viable tumor from necrosis.
A role for ion channels in glioma cell invasion.
TLDR
Evidence is discussed that supports the importance of channel-mediated cell-volume changes in the migration of immature neurons and progenitor cells during development and new unpublished data is presented that demonstrates that Cl(-) and K(+) channels involved in cell shrinkage localize to lipid-raft domains on the invadipodia of glioma cells and that their presence might be regulated by trafficking of these proteins in and out of lipid rafts.
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