Development of the polymer micelle carrier system for doxorubicin.

@article{Nakanishi2001DevelopmentOT,
  title={Development of the polymer micelle carrier system for doxorubicin.},
  author={Toshiyuki Nakanishi and Shigeto Fukushima and Kenichi Okamoto and Masazumi Suzuki and Yasuhiro Matsumura and Masayuki Shinmatsudo-chuoplazaheights Yokoyama and Takaichi Okano and Yasuhisa Sakurai and Kazunori Kataoka},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2001},
  volume={74 1-3},
  pages={
          295-302
        }
}
We show the result of pre-clinical study of NK911, a polymeric micelle carrier system for doxorubicin (DOX). The NK911 micelle carrier consists of polyethyleneglycol and conjugated doxorubicin-polyaspartic acid. It has high hydrophobic inner core, and therefore can entrap the sufficient amount of DOX. NK911 has a small particle size of about 40 nm in diameter that accumulates in tumor tissue by EPR effect showing much stronger activity than the free DOX. We plan to perform a clinical trial at… CONTINUE READING
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