Development of the first metabolite-based LC-MS(n) urine drug screening procedure-exemplified for antidepressants.

@article{Wissenbach2011DevelopmentOT,
  title={Development of the first metabolite-based LC-MS(n) urine drug screening procedure-exemplified for antidepressants.},
  author={Dirk K Wissenbach and Markus R Meyer and Daniela Remane and A. Algora Weber and Hans H Maurer},
  journal={Analytical and bioanalytical chemistry},
  year={2011},
  volume={400 1},
  pages={79-88}
}
In contrast to GC-MS libraries, currently available LC-MS libraries for toxicological detection contain besides parent drugs only some main metabolites limiting their applicability for urine screening. Therefore, a metabolite-based LC-MS(n) screening procedure was developed and exemplified for antidepressants. The library was built up with MS(2) and MS(3) wideband spectra using an LXQ linear ion trap with electrospray ionization in the positive mode and full-scan information-dependent… CONTINUE READING