Development of the fetal bone marrow niche and regulation of HSC quiescence and homing ability by emerging osteolineage cells.

@article{Cokun2014DevelopmentOT,
  title={Development of the fetal bone marrow niche and regulation of HSC quiescence and homing ability by emerging osteolineage cells.},
  author={S{\"u}leyman Coşkun and Hsu Chao and Hema H Vasavada and Kartoosh Heydari and Naomi M Gonzales and Xin Zhou and Benoit de Crombrugghe and Karen K Hirschi},
  journal={Cell reports},
  year={2014},
  volume={9 2},
  pages={581-90}
}
Hematopoietic stem cells (HSCs) reside within a specialized niche where interactions with vasculature, osteoblasts, and stromal components regulate their self-renewal and differentiation. Little is known about bone marrow niche formation or the role of its cellular components in HSC development; therefore, we established the timing of murine fetal long bone vascularization and ossification relative to the onset of HSC activity. Adult-repopulating HSCs emerged at embryonic day 16.5 (E16.5… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 7 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

Similar Papers

Loading similar papers…