Development of the diencephalon in the rat. IV. Quantitative study of the time of origin of neurons and the internuclear chronological gradients in the thalamus

@article{Altman1979DevelopmentOT,
  title={Development of the diencephalon in the rat. IV. Quantitative study of the time of origin of neurons and the internuclear chronological gradients in the thalamus},
  author={Joseph Altman and Shirley A. Bayer},
  journal={Journal of Comparative Neurology},
  year={1979},
  volume={188}
}
Groups of pregnant rats were injected with two successive daily doses of 3H‐thymidine from gestational days 13 and 14 (E13 + 14) until the day before birth (E21 + 22). With this progressively delayed comprehensive labelling procedure we determined the time of origin of neurons in the nuclei of the epithalamus, thalamus, and ventral thalamus. The zona incerta, subthalamic nucleus, are composed of the earliest arising neurons (E13, or before, to E15). The neurons of the lateral habenular nucleus… 
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Development of the diencephalon in the rat. VI. Re‐evaluation of the embryonic development of the thalamus on the basis of thymidine‐radiographic datings
TLDR
Suggestive evidence was obtained that the late arising neurons of the medial thalamus (the anterior nuclei, the mediodorsal nucleus, and some or all of the midline nuclei) originate in a portion of the superior neuroepithelial lobule designated as SL2.
Development of the brain stem in the rat. V. Thymidine‐radiographic study of the time of origin of neurons in the midbrain tegmentum
TLDR
The proportion of neurons generated (no longer labeled) on specific embryonic days was determined quantitatively in 18 regions of the midbrain tegmentum in order to label in embryos the proliferating precursors of neurons.
Development of the rat thalamus: IV. The intermediate lobule of the thalamic neuroepithelium, and the time and site of origin and settling pattern of neurons of the ventral nuclear complex
TLDR
Quantitative examination of long‐survival radiograms established that the bulk of the neurons of the ventral nuclear complex are generated between days E14 and E16 but with statistically significant differences between its three nuclei.
Development of the rat thalamus: V. The posterior lobule of the thalamic neuroepithelium and the time and site of origin and settling pattern of neurons of the medial geniculate body
TLDR
Quantitative evaluation of long‐survival radiograms established that the bulk of MG neurons are generated between embryonic days E13 and E15, with a pronounced peak on day E14, and there is an overall lateral‐to‐medial and caudal‐to-rostral chronological gradient in MG neurogenesis.
Development of the brain stem in the rat. I. Thymidine‐radiographic study of the time of origin of neurons of the lower medulla
TLDR
On the basis of absolute datings, duration of neuron production, intranuclear and internuclear gradients, and other criteria, it is postulated that the neurons of the lower medulla are derived from at least eight different cytogenetic zones.
Time of origin of neurons of the rat inferior colliculus and the relations between cytogenesis and tonotopic order in the auditory pathway
TLDR
The results revealed that in those structures in which a cytogenetic gradient could be recognized, the orientation of this gradient and the regional tonotopic order tended to be aligned, which suggested that the orderly production of neurons within different components of the auditory system is a factor in their subsequent topographic organization.
Development of the rat thalamus: III. Time and site of origin and settling pattern of neurons of the reticular nucleus
TLDR
Rat embryos, fetuses, and young pups were analyzed in order to examine the time of origin, settling pattern, migratory route, and site of origin of neurons of the reticular nuclear complex of the thalamus.
Development of the rat thalamus: VI. The posterior lobule of the thalamic neuroepithelium and the time and site of origin and settling pattern of neurons of the lateral geniculate and lateral posterior nuclei
TLDR
Examination of radiograms of rat embryos, fetuses, and young pups indicated that the neurons of the LGD originate in a discrete neuroepithelial eversion situated ventral to the pineal rudiment and dorsal to the putative Neuroepithelium of the ventral nuclear complex.
Development of the diencephalon in the rat. V. Thymidine‐radiographic observations on internuclear and intranuclear gradients in the thalmus
Groups of pregnant rats were injected with two successive daily doses of 3H‐thymidine from gestational days 13 and 14 (E13 + 14) until the day before birth (E21 + 22). Internuclear and intranuclear…
Development of the brain stem in the rat. IV. Thymidine‐radiographic study of the time of orgin of neurons in the pontine region
TLDR
At 60 days of age the proportion of neurons generated (or no longer labeled) on specific embryonic days was determined quantitatively in 14 nuclei of the pontine region.
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TLDR
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