Development of the brain stem in the rat. I. Thymidine-radiographic study of the time of origin of neurons of the lower medulla.

@article{Altman1980DevelopmentOT,
  title={Development of the brain stem in the rat. I. Thymidine-radiographic study of the time of origin of neurons of the lower medulla.},
  author={Joseph Altman and Shirley A. Bayer},
  journal={The Journal of comparative neurology},
  year={1980},
  volume={194 1},
  pages={1-35}
}
Groups of pregnant rats were injected with two successive daily doses of 3H-thymidine from gestational days 12 and 13 (E12 + 13) until the day before birth (E21 + 22). In adult progeny of the injected rats the proportion of neurons generated on specific days was determined quantitatively in the major nuclei of the lower medulla. The earliest generated cells form two motor nuclei: the hypoglossal and dorsal vagal nuclei. The bulk of hypoglossal neurons are produced on day E12, with a small… CONTINUE READING