Development of the adrenergic phenotype : Increase in adrenal messenger RNA coding for phenylethanolamine-N-methyltransferase ( epinephrine / ontogeny / translation / gene expression / cell differentiation )

Abstract

Mechanisms regulating the developmental increase in the activity of adrenal phenylethanolamine-N-methyltransferase (PNMTase), an index of the adrenergic phenotype, were examined. Immunotitration indicated that the increase in catalytic activity in rat adrenal from birth to adulthood was attributable to increased numbers of PNMTase molecules, not enzyme… (More)

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