Development of the Home Pregnancy Test

  title={Development of the Home Pregnancy Test},
  author={Judith L. Vaitukaitis},
  journal={Annals of the New York Academy of Sciences},
  • J. Vaitukaitis
  • Published 1 December 2004
  • Medicine
  • Annals of the New York Academy of Sciences
Abstract: The home pregnancy testworks by measuring human chorionic gonadotropin (hCG) hormone in urine. This hormone was initially studied in NICHD intramural laboratories as a reliable marker of certain tumors. Refinement of the assay for hCG detection to enhance specificity enabled its ready application to pregnancy detection. 

Comparison of accuracy and certainty of results of six home pregnancy tests available over-the-counter

The Clearblue Digital Pregnancy Test (CBDPT) was significantly better in terms of accuracy and certainty than non-digital OTC HPTs tested at a low hCG concentration and demonstrates that a digital reading offers significant benefits to the consumer over traditional non- digital tests.

The long gestation of the modern home pregnancy test.

The ability of women to confirm their pregnancies in the privacy of their own homes was described as a “private little revolution” 35 years ago, when the early version of the modern home pregnancy

Maternal Responsibility and Traceable Loss: medicine and miscarriage in twentieth-century Australia

The meaning of miscarriage in twentieth century Australia is historicised and a number of crucial turning points in scientific interpretations of the causes and treatments of miscarriage that produced shifts in the communication of responsibility to women for their own pregnancy losses are identified.

Comparison of volunteers' experience of using, and accuracy of reading, different types of home pregnancy test formats.

In this study, the branded midstream digital test was superior to other tests evaluated and fulfilled the criteria of being an easy-to-use and interpret test; strip and cassette tests showed poor performance in women's hands.

Human Plasma Proteome During Normal Pregnancy.

The results suggested that the plasma proteome may provide a non-invasive readout of placental cellular dynamics and serve as a blueprint for investigating obstetrical disease.

The evolution of rapid antigen detection systems and their application for COVID-19 and other serious respiratory infectious diseases

Review on Application of Gold Nanoparticles and Paper-based Microfluidic Analytical Device in Detection of Human Chorionic Gonadotropin

Human chorionic gonadotropin (HCG) has been amongst of essential part of medical diagnostics in gynaecology and oncology since its discovery. Application of gold nanoparticles in detecting HCG is due



Appearance of hCG in pregnancy plasma following the initiation of implantation of the blastocyst.

Results indicate that hCG does not appear in the maternal circulation until after the initiation of implantation of the blastocyst, and that the first significant rise in plasma hCG occurred 9 to 13 days after ovulation.

Human chorionic gonadotropin as a tumor marker.

  • J. Vaitukaitis
  • Medicine, Biology
    Annals of clinical and laboratory science
  • 1974
Patients with tumors of the stomach, liver, ovary and testis were found to have the highest incidence of ectopic hCG secretion.

Changing placental concentrations of human chorionic gonadotropin and its subunits during gestation.

  • J. Vaitukaitis
  • Biology, Medicine
    The Journal of clinical endocrinology and metabolism
  • 1974
The absolute amount of hCG and hCGα decreased after the first trimester but the relative quantity of h CGα exceeded that for immunoreactive hCG by more than 10-fold in the last two trimesters.

Evidence for altered synthesis of human chorionic gonadotropin in gestational trophoblastic tumors.

The most striking finding was the absence of free circulating hCGalpha in the sera in patients with gestational trophoblastic disease which responded to chemotherapy, since free hC Galpha is readily detectable in theSera of normally pregnant women.

Editorial: When is a tumor marker not a tumor marker?

Almost all the biologically active protein and polypeptide hormones, including those synthesized and secreted by the normal placenta, have been implicated in ectopic humoral syndromes associated wi...

Specific radioimmunoassay of chorionic gonadotropin during implantation in rhesus monkeys.

These findings demonstrate that the attaching blastocyst or the developing syncytiotrophoblast either already possesses or rapidly attains the capacity to secrete mCG.

Hormonal factors influencing ovarian uptake of human chorionic gonadotropin.

The ovarian uptake of tritiated human chorionic gonadotropin (3H—hCG) in hypophysectomized rats was investigated and correlated with ovarian morphology after treatment with various combinations of

Properties of the subunits of human chorionic gonadotropin.

The preparation and properties of hCG and its subunits hCGα and hCGβ (CR115, CR117 and CR119) are described and gel electrophoresis indicates that they are contaminated with less than 2% by weight of the complementary subunit.