Development of the Double Cyclic Peptide Ligand for Antibody Purification and Protein Detection.

Abstract

Development of a peptide-based affinity matrix and detection reagent is important for biomedical research and the biopharmaceutical industry. In the present work, we designed and synthesized an immunoglobin G (IgG)-binding peptide ligand, Fc-III-4C. Fc-III-4C is composed of 15 residues, and the 4 cysteine residues form 2 disulfide bonds to generate a double… (More)
DOI: 10.1021/acs.bioconjchem.6b00170

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