Development of the Copper-Catalyzed Olefin Aziridination Reaction

  title={Development of the Copper-Catalyzed Olefin Aziridination Reaction},
  author={David A.D. Evans and Mark T Bilodeau and Margaret M. Faul},
Soluble Cu(1) and Cu(I1) triflate and perchlorate salts are efficient catalysts for the aziridination of olefins employing (N-@-tolylsulfonyl)imino)phenyliodinane, PhI=NTs, as the nitrene precursor. Electron-rich as well as electron-deficient olefins undergo aziridination with this reagent in 55-958 yields, at temperatures ranging from -20 OC to +25 OC. The catalyzed nitrogen atom-transfer reaction to enol silanes and silylketene acetals has also been developed to provide facile syntheses of a… CONTINUE READING