Development of the CD4 and CD8 lineage of T cells: instruction versus selection.

@article{Borgulya1991DevelopmentOT,
  title={Development of the CD4 and CD8 lineage of T cells: instruction versus selection.},
  author={Peter Borgulya and Hiroyuki Kishi and Ulrich F M{\"u}ller and Joerg Kirberg and Harald von Boehmer},
  journal={The EMBO journal},
  year={1991},
  volume={10 4},
  pages={913-8}
}
T cells bearing the alpha beta T cell receptor (TCR) can be divided into CD4+8- and CD4-8+ subsets which develop in the thymus from CD4+8+ precursors. The commitment to the CD4 and CD8 lineage depends on the binding of the alpha beta TCR to thymic major histocompatibility complex (MHC) coded class II and class I molecules, respectively. In an instructive model of lineage commitment, the binding of the alpha beta TCR, for instance to class I MHC molecules, would generate a specific signal… CONTINUE READING

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