Development of tetraploidy in V79 spheroids


Chinese hamster V-79-171 cells, when placed in suspension culture, spontaneously form multicell spheroids. As the spheroids enlarge the fraction of polyploid (predominantly tetraploid) cells increases and can approach 100% in very large spheroids. Spheroid size, rather than age, seems to be a major determinant for increased ploidy. When cell separation… (More)
DOI: 10.1007/BF02796426


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@article{Olive1982DevelopmentOT, title={Development of tetraploidy in V79 spheroids}, author={Peggy L. Olive and Joshua C Leonard and Ralph E. Durand}, journal={In Vitro - Plant}, year={1982}, volume={18}, pages={708-714} }