Development of tau PET Imaging Ligands and their Utility in Preclinical and Clinical Studies.

@article{Choi2018DevelopmentOT,
  title={Development of tau PET Imaging Ligands and their Utility in Preclinical and Clinical Studies.},
  author={Yoori Choi and Seunggyun Ha and Yun-Sang Lee and Yun Kyung Kim and Dong Soo Lee and Dong Jin Kim},
  journal={Nuclear medicine and molecular imaging},
  year={2018},
  volume={52 1},
  pages={24-30}
}
The pathological features of Alzheimer's disease are senile plaques which are aggregates of β-amyloid peptides and neurofibrillary tangles in the brain. Neurofibrillary tangles are aggregates of hyperphosphorylated tau proteins, and these induce various other neurodegenerative diseases, such as progressive supranuclear palsy, corticobasal degeneration, frontotemporal lobar degeneration, frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), and chronic traumatic… CONTINUE READING
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