Development of synchronous VHL syndrome tumors reveals contingencies and constraints to tumor evolution

Abstract

Genomic analysis of multi-focal renal cell carcinomas from an individual with a germline VHL mutation offers a unique opportunity to study tumor evolution. We perform whole exome sequencing on four clear cell renal cell carcinomas removed from both kidneys of a patient with a germline VHL mutation. We report that tumors arising in this context are clonally… (More)
DOI: 10.1186/s13059-014-0433-z

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