Development of stage-dependent glycans on the Fc domains of IgG antibodies of ALS animals.


We recently revealed a unique glycan on the Fc domain of IgG antibodies in ALS patients that mediates antibody-dependent cell cytotoxicity (ADCC). This glycan has a bi-antennary structure that lacks the core fucose and sialic acid residues but contains a bisecting GlcNAc (A2BG2). Little is known, however, about the incidence of A2BG2 expression and IgG… (More)
DOI: 10.1016/j.expneurol.2015.02.023