Development of spontaneous anergy in invariant natural killer T cells in a mouse model of dyslipidemia.

@article{Braun2010DevelopmentOS,
  title={Development of spontaneous anergy in invariant natural killer T cells in a mouse model of dyslipidemia.},
  author={Nicole A. Braun and Yanice V. Mendez-Fernandez and Roman Covarrubias and Steven A Porcelli and Paul B Savage and Hideo Yagita and Luc Van Kaer and Amy S. Major},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2010},
  volume={30 9},
  pages={
          1758-65
        }
}
  • Nicole A. Braun, Yanice V. Mendez-Fernandez, +5 authors Amy S. Major
  • Published in
    Arteriosclerosis, thrombosis…
    2010
  • Medicine, Biology
  • OBJECTIVE In this study, we investigated whether dyslipidemia-associated perturbed invariant natural killer T (iNKT) cell function is due to intrinsic changes in iNKT cells or defects in the ability of antigen-presenting cells to activate iNKT cells. METHODS AND RESULTS We compared iNKT cell expansion and cytokine production in C57BL/6J (B6) and apolipoprotein E-deficient (apoE(-/-)) mice. In response to in vivo stimulation with alpha-galactosylceramide, a prototypic iNKT cell glycolipid… CONTINUE READING

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