Development of small molecule non-peptide formyl peptide receptor (FPR) ligands and molecular modeling of their recognition.

@article{Schepetkin2014DevelopmentOS,
  title={Development of small molecule non-peptide formyl peptide receptor (FPR) ligands and molecular modeling of their recognition.},
  author={Igor A Schepetkin and Andrei I. Khlebnikov and Maria Paola Giovannoni and Liliya N. Kirpotina and Agostino Cilibrizzi and Mark T Quinn},
  journal={Current medicinal chemistry},
  year={2014},
  volume={21 13},
  pages={
          1478-504
        }
}
Formyl peptide receptors (FPRs) are G protein-coupled receptors (GPCRs) expressed on a variety of cell types. These receptors play an important role in the regulation of inflammatory reactions and sensing cellular damage. They have also been implicated in the pathogenesis of various diseases, including neurodegenerative diseases, cataract formation, and atherogenesis. Thus, FPR ligands, both agonists and antagonists, may represent novel therapeutics for modulating host defense and innate… CONTINUE READING
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