Development of sensors for direct detection of organophosphates. Part I: Immobilization, characterization and stabilization of acetylcholinesterase and organophosphate hydrolase on silica supports.

@article{Singh1999DevelopmentOS,
  title={Development of sensors for direct detection of organophosphates. Part I: Immobilization, characterization and stabilization of acetylcholinesterase and organophosphate hydrolase on silica supports.},
  author={Anup Singh and A. W. Flounders and Joanne V Volponi and C. Maria Sylvia Ashley and K. D. Wally and Joseph S. Schoeniger},
  journal={Biosensors & bioelectronics},
  year={1999},
  volume={14 8-9},
  pages={703-13}
}
Biosensors for organophosphates in solution may be constructed by monitoring the activity of acetylcholinesterase (AChE) or organophosphate hydrolase (OPH) immobilized to a variety of microsensor platforms. The area available for enzyme immobilization is small (< 1 mm2) for microsensors. In order to construct microsensors with increased surface area for enzyme immobilization, we used a sol-gel process to create highly porous and stable silica matrices. Surface porosity of sol-gel coated… CONTINUE READING
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