Development of sensitive and specific age- and gender-specific low-density lipoprotein cholesterol cutoffs for diagnosis of first-degree relatives with familial hypercholesterolaemia in cascade testing.

@article{Starr2008DevelopmentOS,
  title={Development of sensitive and specific age- and gender-specific low-density lipoprotein cholesterol cutoffs for diagnosis of first-degree relatives with familial hypercholesterolaemia in cascade testing.},
  author={Brian Starr and Sophie Hadfield and Barbara A. Hutten and Peter J Lansberg and Trond P. Leren and Dorte Winther Damgaard and H. Andrew W. Neil and Steve E Humphries},
  journal={Clinical chemistry and laboratory medicine},
  year={2008},
  volume={46 6},
  pages={791-803}
}
BACKGROUND The plasma total and low-density lipoprotein-cholesterol (LDL-C) levels that are used as diagnostic criteria for familial hypercholesterolaemia (FH) probands in the general population are too stringent for use in relatives, given the higher prior probability of a first-degree relative being FH (50% vs. 1/500). Our objective was therefore to develop more appropriate LDL-C cutoffs to identify "affected" first-degree relatives found by cascade testing, to test their accuracy and utility… CONTINUE READING
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