Development of self emulsifying lipid formulations of BCS class II drugs with low to medium lipophilicity.

@article{Jannin2015DevelopmentOS,
  title={Development of self emulsifying lipid formulations of BCS class II drugs with low to medium lipophilicity.},
  author={Vincent Jannin and St{\'e}phanie Chevrier and Matthieu Michenaud and Camille Dumont and Silvia Belotti and Yann Chavant and Fr{\'e}d{\'e}ric Demarne},
  journal={International journal of pharmaceutics},
  year={2015},
  volume={495 1},
  pages={
          385-392
        }
}
Lipid-based formulations can be effective drug delivery systems for poorly water-soluble chemical entities, provided they are designed with careful selection of the excipients, based on their role in the delivery system and in relation to drug properties. The primary factor leading to increased bioavailability is the administration of the drug in a pre-dissolved state thereby avoiding the dissolution limiting step. All model drugs tested (piroxicam, curcumin and nifedipine) belong to the same… CONTINUE READING

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