Development of rhizosecretion as a production system for recombinant proteins from hydroponic cultivated tobacco.

@article{Drake2009DevelopmentOR,
  title={Development of rhizosecretion as a production system for recombinant proteins from hydroponic cultivated tobacco.},
  author={Pascal M. W. Drake and Tommaso Barbi and Amy L. Sexton and Edward G. McGowan and Johannes Stadlmann and Catherine Navarre and Matthew J Paul and Julian K-C Ma},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2009},
  volume={23 10},
  pages={3581-9}
}
Rhizosecretion is an attractive technology for the production of recombinant proteins from transgenic plants. However, to date, yields of plant-derived recombinant pharmaceuticals by this method have been too low for commercial viability. Studies conducted focused on three transgenic plant lines grown in hydroponic culture medium, two expressing monoclonal antibodies Guy's 13 and 4E10 and one expressing a small microbicide polypeptide cyanovirin-N. Rhizosecretion rates increased significantly… CONTINUE READING