Development of resistance during antimicrobial therapy: a review of antibiotic classes and patient characteristics in 173 studies.

@article{Fish1995DevelopmentOR,
  title={Development of resistance during antimicrobial therapy: a review of antibiotic classes and patient characteristics in 173 studies.},
  author={Douglas N. Fish and Stephen C. Piscitelli and Larry H. Danziger},
  journal={Pharmacotherapy},
  year={1995},
  volume={15 3},
  pages={279-91}
}
The incidence of emergent resistance and clinical factors affecting its development were evaluated by retrospective review of 173 studies encompassing over 14,000 patients. Eight antibiotic classes and 225 individual treatment regimens were evaluated. Emergent resistance occurred among 4.0% of all organisms and 5.6% of all infections treated. It appeared to be significantly more frequent with penicillin and aminoglycoside monotherapy, with significantly lower rates associated with imipenem… CONTINUE READING

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