Development of recombinant hepatitis C virus with NS5A from strains of genotypes 1 and 2.

Abstract

Nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) plays multiple and diverse roles in the viral lifecycle, and is currently recognized as a novel target for anti-viral therapy. To establish an HCV cell culture system with NS5A of various strains, recombinant viruses were generated by replacing NS5A of strain JFH-1 with those of strains of genotypes… (More)
DOI: 10.1016/j.bbrc.2011.05.144

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Cite this paper

@article{Okamoto2011DevelopmentOR, title={Development of recombinant hepatitis C virus with NS5A from strains of genotypes 1 and 2.}, author={Yuka Okamoto and Takahiro Masaki and Asako Murayama and T. Munakata and Akio Nomoto and Shingo Nakamoto and Osamu Yokosuka and Haruo Watanabe and Takaji Wakita and Takanobu Kato}, journal={Biochemical and biophysical research communications}, year={2011}, volume={410 3}, pages={404-9} }