Development of real-time in vivo imaging of device-related Staphylococcus epidermidis infection in mice and influence of animal immune status on susceptibility to infection.

@article{Vuong2008DevelopmentOR,
  title={Development of real-time in vivo imaging of device-related Staphylococcus epidermidis infection in mice and influence of animal immune status on susceptibility to infection.},
  author={Cuong Vuong and Stanislava Kocianova and Jun Yu and Jagath L. Kadurugamuwa and Michael Otto},
  journal={The Journal of infectious diseases},
  year={2008},
  volume={198 2},
  pages={
          258-61
        }
}
Staphylococcus epidermidis is the leading cause of hospital-acquired device-related infections, but there is a lack of suitable methods to investigate the pathogenesis of S. epidermidis infection. We created a bioluminescent strain of S. epidermidis and developed a subcutaneous catheter-related murine infection model for real-time monitoring of biofilm-associated infection. Additionally, we compared severely immunocompromised and immunocompetent mice, demonstrating the substantial effect of… CONTINUE READING
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