Development of radioimmunoassays for trifluoperazine and their application to metabolic studies of the drug.

@article{Midha1983DevelopmentOR,
  title={Development of radioimmunoassays for trifluoperazine and their application to metabolic studies of the drug.},
  author={K. Midha and E. Hawes and G. Rauw and G. Mckay and J. K. Cooper and H. U. Shetty},
  journal={Journal of pharmacological methods},
  year={1983},
  volume={9 4},
  pages={
          283-93
        }
}
Antisera to trifluoperazine have been raised in New Zealand white rabbits to several different types of immunogens, where there was variation in the length and nature of the side chain attached to the phenothiazine nucleus, as well as in the number of hapten residues coupled to bovine serum albumin. A radioimmunoassay for trifluoperazine has been developed which is capable of quantitating 0.3125 ng ml-1 in a 200 microliter plasma sample, with cross-reactivities to the sulfoxide, 7-hydroxy, and… Expand
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