Development of radiochemically pure antibodies.

@article{Eckelman1990DevelopmentOR,
  title={Development of radiochemically pure antibodies.},
  author={William C. Eckelman},
  journal={Cancer research},
  year={1990},
  volume={50 3 Suppl},
  pages={
          780s-782s
        }
}
There are presently three approaches to radiolabeling antibodies: direct radiolabeling; radiolabeling of a chelating agent conjugated to an antibody; and radiolabeling of a chelating agent before conjugation to an antibody. Using either the direct radiolabeling or radiolabeling of a chelating agent conjugated to an antibody has not led to a radiochemically pure 99mTc-labeled protein. High radiochemical purity is obtained using a prelabeled ligand; therefore this method is preferred. 

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