Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females

@inproceedings{Dempsie2011DevelopmentOP,
  title={Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females},
  author={Yvonne Dempsie and Margaret Nilsen and Kevin White and Kirsty M. Mair and Lynn Loughlin and Noona S Ambartsumian and Marlene Rabinovitch and Margaret R. Maclean},
  booktitle={Respiratory research},
  year={2011}
}
BACKGROUND Idiopathic and familial forms of pulmonary arterial hypertension (PAH) occur more frequently in women than men. However, the reason for this remains unknown. Both the calcium binding protein S100A4/Mts1 (Mts1) and its endogenous receptor (receptor for advanced glycosylation end products; RAGE) have been implicated in the development of PAH. We wished to investigate if the Mts1/RAGE pathway may play a role in the gender bias associated with PAH. METHODS We investigated the effects… CONTINUE READING

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