Development of proteasome inhibitors as research tools and cancer drugs

@inproceedings{Goldberg2012DevelopmentOP,
  title={Development of proteasome inhibitors as research tools and cancer drugs},
  author={Alfred L Goldberg},
  booktitle={The Journal of cell biology},
  year={2012}
}
The proteasome is the primary site for protein degradation in mammalian cells, and proteasome inhibitors have been invaluable tools in clarifying its cellular functions. The anticancer agent bortezomib inhibits the major peptidase sites in the proteasome's 20S core particle. It is a "blockbuster drug" that has led to dramatic improvements in the treatment of multiple myeloma, a cancer of plasma cells. The development of proteasome inhibitors illustrates the unpredictability, frustrations, and… CONTINUE READING
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Bortezomib’s scientific origins and its tortuous path to the clinic

  • A. L. Goldberg
  • Bortezomib in the Treatment of Multiple Myeloma…
  • 2011
Highly Influential
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