Development of protease activated interleukin-12 cytokine fusion proteins for tumor immunotherapy (TUM7P.946)

@inproceedings{Skrombolas2014DevelopmentOP,
  title={Development of protease activated interleukin-12 cytokine fusion proteins for tumor immunotherapy (TUM7P.946)},
  author={Denise Skrombolas and Shivana Maharaj and I. A. R. Wylie and Mark A. Sullivan and Gautam N Shenoy and Richard B Bankert and John G. Frelinger},
  year={2014}
}
Local expression of IL-12 in the tumor microenvironment results in greatly enhanced anti-tumor responses. However, achieving local expression of cytokines at disseminated sites is challenging and systemic delivery has significant toxicity. We describe a novel approach employing an activatable fusion protein (FP) to reduce the negative side-effects of systemic delivery of the cytokine but which can preferentially affect all tumor sites. This FP consists of a cytokine linked to an inhibitory… CONTINUE READING

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