Development of prostate-specific antigen promoter-based gene therapy for androgen-independent human prostate cancer.

@article{Gotoh1998DevelopmentOP,
  title={Development of prostate-specific antigen promoter-based gene therapy for androgen-independent human prostate cancer.},
  author={Akinobu Gotoh and Sung Chan Ko and Takahashi Shirakawa and Jun Cheon and Chinghai Kao and Takahide Miyamoto and Thomas Allen Gardner and Ling-Jun Ho and C B J M Cleutjens and Jan Trapman and Frank L. Graham and Leland W. K. Chung},
  journal={The Journal of urology},
  year={1998},
  volume={160 1},
  pages={220-9}
}
PURPOSE The goal of this study is to develop a tissue-specific toxic gene therapy utilizing the prostate specific antigen (PSA) promoter for both androgen-dependent (AD) and androgen-independent (AI) PSA-secreting prostate cancer cells. Ideally this gene therapy would be effective without the necessity of exposing the target cells to circulating androgens. MATERIALS AND METHODS An AI subline of LNCaP, an AD PSA-secreting human prostate cancer cell line, C4-2, was used in this study. Castrated… CONTINUE READING

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