Development of progressive aortic vasculopathy in a rat model of aging.

  title={Development of progressive aortic vasculopathy in a rat model of aging.},
  author={Steven J. Miller and William C. Watson and Kimberly A Kerr and Carlos Alberto Labarrere and Neal X. Chen and Mark A. Deeg and Joseph L. Unthank},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={293 5},
Recent studies have established that age is the major risk factor for vascular disease. Numerous aberrant changes occur in vascular structure and function during aging, and animal models are the primary means to determine the underlying mechanisms of age-mediated vascular pathology. The Fischer 344/Brown Norway F1 hybrid (F344xBN) rat thoracic aorta has been shown to display age-related pathology similar to what occurs in humans. This study utilized the F344xBN rat aorta and both morphometric… CONTINUE READING
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