Development of programmable small DNA-binding molecules with epigenetic activity for induction of core pluripotency genes.

Abstract

Epigenetic modifications that govern the gene expression are often overlooked with the design of artificial genetic switches. N-Methylpyrrole-N-methylimidazole (PI) hairpin polyamides are programmable small DNA binding molecules that have been studied in the context of gene regulation. Recently, we synthesized a library of compounds by conjugating PI… (More)
DOI: 10.1016/j.bmc.2012.02.032

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@article{Pandian2012DevelopmentOP, title={Development of programmable small DNA-binding molecules with epigenetic activity for induction of core pluripotency genes.}, author={Ganesh N. Pandian and Akimichi Ohtsuki and Toshikazu Bando and Shinsuke Sato and Kaori Hashiya and Hiroshi Sugiyama}, journal={Bioorganic & medicinal chemistry}, year={2012}, volume={20 8}, pages={2656-60} }