Development of prenatal screening--A historical overview.


The first prenatal screening test to be introduced was based on a single maternal serum marker of neural tube defects. Since then various prenatal screening concepts have been developed, the most successful being Down syndrome risk estimation using multiple serum and ultrasound markers. Today a completely new approach to aneuploidy screening is available… (More)
DOI: 10.1053/j.semperi.2015.11.003


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