Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups.

Abstract

A series of compounds incorporating both sulfonamide and sulfamide as zinc-binding groups (ZBGs) are reported as inhibitors of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1). Crystallographic studies on the complex of hCA II with the lead compound of this series, namely, 4-sulfamido-benzenesulfonamide, revealed the binding of two molecules in the… (More)
DOI: 10.1021/jm300818k

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