Development of population-based newborn screening for severe combined immunodeficiency.

@article{Chan2005DevelopmentOP,
  title={Development of population-based newborn screening for severe combined immunodeficiency.},
  author={Kee Chan and Jennifer M Puck},
  journal={The Journal of allergy and clinical immunology},
  year={2005},
  volume={115 2},
  pages={391-8}
}
BACKGROUND Severe combined immunodeficiency (SCID) is a treatable, inherited lack of cellular and humoral immunity caused by diverse mutations in several different genes and leading to death in infancy unless immune reconstitution is provided. Currently no population screening exists for SCID, but early diagnosis would improve outcome. OBJECTIVE Because all patients with SCID make few or no T cells, we asked whether the absence of T-cell receptor excision circles (TRECs), DNA episomes in… CONTINUE READING
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