Development of platelets during steady state and inflammation

@article{MllerNewen2017DevelopmentOP,
  title={Development of platelets during steady state and inflammation},
  author={Gerhard M{\"u}ller-Newen and Matthias B. Stope and Thomas Kraus and Patrick Ziegler},
  journal={Journal of Leukocyte Biology},
  year={2017},
  volume={101}
}
Megakaryocytes (MK) are the sole source of platelets in the body. They develop from lineage‐committed hematopoietic stem and progenitor cells (HSPCs) via intermediate cells, which differ in morphology, size, ploidy, and surface phenotype. Development and maturation of MKs is governed by different transcription factors, including GATA‐1, E26 transformation‐specific transcription factor (ETS) family members, nuclear factor erythroid 2 transcription factor (NF‐E2), and STAT3. During such… 
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