Development of plasmacytoid cells with Russell bodies in autoimmune "viable motheaten" mice.

@article{Shultz1987DevelopmentOP,
  title={Development of plasmacytoid cells with Russell bodies in autoimmune "viable motheaten" mice.},
  author={Leonard D Shultz and D. R. Coman and Bonnie L. Lyons and Charles L. Sidman and Stephen Taylor},
  journal={The American journal of pathology},
  year={1987},
  volume={127 1},
  pages={38-50}
}
Mice homozygous for the autosomal recessive mutation "viable motheaten" (mev) are severely immunodeficient, show polyclonal B-cell activation, and express multiple autoantibodies over a maximum life span of 25 weeks. Lymphoid tissues from these mice contain large numbers of atypical plasma cells in which discrete glycoprotein inclusions are found within the endoplasmic reticulum. Such plasma cells are termed "Mott cells," and the inclusions are called "Russell bodies." Dense accumulations of… CONTINUE READING