Development of physiologically based pharmacokinetic model for methyl tertiary-butyl ether and tertiary-butanol in male Fisher-344 rats.

@article{Borghoff1996DevelopmentOP,
  title={Development of physiologically based pharmacokinetic model for methyl tertiary-butyl ether and tertiary-butanol in male Fisher-344 rats.},
  author={Susan J. Borghoff and James E J Murphy and Michele Medinsky},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1996},
  volume={30 2},
  pages={264-75}
}
Methyl tertiary-butyl ether (MTBE) and its metabolite tertiary-butanol (TBA) both cause renal tumors in chronically exposed male rats. Knowledge of the kinetic behavior of MTBE and TBA in rats and its comparison to the kinetics of these chemicals in humans will aid in assessing human risk. The objective of this study was to develop a physiologically based pharmacokinetic (PBPK) model for MTBE and TBA in rats that will form the basis for a human model. Physiological parameters such as blood… CONTINUE READING

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