Development of peptide and small-molecule HIV-1 fusion inhibitors that target gp41.

Abstract

It has been 25 years since the development of the first efficient HIV-1/AIDS treatment. Scientists now know more about the HIV-1 infection life cycle, and more than 30 antiretroviral drugs have been developed, including HIV-1 fusion inhibitors. Fundamental work was begun in the early 1990s and led to the development of a novel class of anti-HIV-1 drugs… (More)
DOI: 10.1002/cmdc.201000289

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