Development of particulate pulse-release formulations and their mathematical description

  title={Development of particulate pulse-release formulations and their mathematical description},
  author={Paul J. A. Hartman Kok and Pieter Willem Vonk and Mark Hoekzema and N. W. F. Kossen},
  journal={Powder Technology},
Mechanistic model for drug release during the lag phase from pellets coated with a semi-permeable membrane.
A new mechanistic model of drug release during the lag phase from coated pellets undergoing cracking in the coating due to the hydrostatic pressure built up inside the pellet has been developed and allows the prediction of the lag time prior to crack formation.
Development and Mathematical Simulation of Theophylline Pulsatile Release Tablets
Results showed that ethylcellulose was the best candidate polymer for pulsatile release tablets andRupture time increased with increasing the amount of the plasticizer, but 15% plasticizer provided the best release profiles.
Film coatings for oral pulsatile release.
Ammonio Polymethacrylate-Coated Diltiazem: Drug Release from Single Pellets, Media Dependence, and Swelling Behavior
Drug release from single pellets was measured on an easily assembled flow-through system. Despite heterogeneity between pellets, the sum of the individual results resembled drug release from an
Oral pulsatile drug delivery systems
The rational and prominent design strategies behind oral pulsatile delivery are outlined, including single- or multiple-unit systems provided with release-controlling coatings, capsular devices and osmotic pumps.
Formulation design, challenges, and development considerations for fixed dose combination (FDC) of oral solid dosage forms
An overview to pharmaceutical scientists about recent trends in the formulation development of the FDC products is given and decision trees to select most optimum formulation development strategy are provided.


Development of a novel drug release system, time-controlled explosion system (TES). I. Concept and design.
A novel controlled drug release system that is characterized by a rapid drug release with a precisely programmed lag time, and a combination of TES particles possessing different lag times could offer any desired release profile of the model compound, metoprolol.
Development of a Novel Drug Release System, Time-Controlled Explosion System (TES). III. Relation between Lag Time and Membrane
To describe lag time of Time-Controlled Explosion System (TES), the system's water absorption kinetics was investigated. Study of water absorption in TES with EC membrane revealed the following
Development of a Novel Drug Release System, Time-Controlled Explosion System (TES). II. Design of Multiparticulate TES and in Vitro Drug Release Properties
For the design of multiparticulate Time-Controlled Explosion System (TES), the thickness of the swelling agent layer was optimized by determining the amount of drug released. Low-substituted
Properties of Aqueous, Plastic Izer-Containing Ethyl Cellulose Dispersions and Prepared Films in Respect to the Production of oral Extended Release Formulations
AbstractPlasticized aqueous ethyl cellulose (EC) dispersions (AquacoatR ECD-30) are incompatible with concentrated electrolytes but stable with nonelectrolytes. The minimum film formation temperature
Novel drug delivery and its therapeutic application
The need for improved drug delivery in clinical practice and the prodrug approach for improved rectal delivery clinical use and future of parenteral microsphere delivery systems are considered.
Numerical recipes in C
The Diskette v 2.06, 3.5''[1.44M] for IBM PC, PS/2 and compatibles [DOS] Reference Record created on 2004-09-07, modified on 2016-08-08.