Development of osteomalacia in a post-liver transplant patient receiving adefovir dipivoxil.

@article{Minemura2010DevelopmentOO,
  title={Development of osteomalacia in a post-liver transplant patient receiving adefovir dipivoxil.},
  author={Masami Minemura and Yoshiharu Tokimitsu and Kazuto Tajiri and Yasuhiro Nakayama and Kengo Kawai and Hiroshi Kudo and Katsuharu Hirano and Yoshinari Atarashi and Yutaka Yata and Satoshi Yasumura and Terumi Takahara and Toshiro Sugiyama},
  journal={World journal of hepatology},
  year={2010},
  volume={2 12},
  pages={442-6}
}
We report the case of a patient treated with living donor-related liver transplantation who suffered from osteomalacia during adefovir dipivoxil (ADV)-containing antiviral therapy for lamivudine-resistant hepatitis B virus infection. The patient had generalized bone pain, with severe hypophosphatemia after 20 mo of ADV therapy. Radiographic studies demonstrated the presence of osteomalacia. The peak plasma ADV level was 38 ng/mL after administration of ADV at 10 mg/d. It was also found that ADV… CONTINUE READING

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