Development of oral dosage form for elderly patients: use of agar as base of rapidly disintegrating oral tablets.

@article{Ito1996DevelopmentOO,
  title={Development of oral dosage form for elderly patients: use of agar as base of rapidly disintegrating oral tablets.},
  author={Akira Ito and Minako Sugihara},
  journal={Chemical & pharmaceutical bulletin},
  year={1996},
  volume={44 11},
  pages={2132-6}
}
Rapidly disintegrating tablets as an oral dosage form for elderly patients with impaired swallowing were investigated using agar powders (AG) or treated agar powders (TAG). When the compression pressure was changed from 0.4 to 2.0 ton/cm2, the disintegration time of AG tablets increased from about 60 to about 160s, and the hardness significantly increased from 3 to 13 kgw. The disintegration time and hardness of the TAG tablets were scarcely affected by the compression pressure: the… CONTINUE READING

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