Development of novel tumor-targeted theranostic nanoparticles activated by membrane-type matrix metalloproteinases for combined cancer magnetic resonance imaging and therapy.

@article{Ansari2014DevelopmentON,
  title={Development of novel tumor-targeted theranostic nanoparticles activated by membrane-type matrix metalloproteinases for combined cancer magnetic resonance imaging and therapy.},
  author={Celina Ansari and Grigory Tikhomirov and Su Hyun Hong and Robert A Falconer and Paul M. Loadman and Jason H Gill and Rosalinda T Casta{\~n}eda and Florette K. Hazard and Ling Tong and Olga D. Lenkov and Dean W. Felsher and Jianghong Rao and Heike Elisabeth Daldrup-Link},
  journal={Small},
  year={2014},
  volume={10 3},
  pages={
          566-75, 417
        }
}
A major drawback with current cancer therapy is the prevalence of unrequired dose-limiting toxicity to non-cancerous tissues and organs, which is further compounded by a limited ability to rapidly and easily monitor drug delivery, pharmacodynamics and therapeutic response. In this report, the design and characterization of novel multifunctional "theranostic" nanoparticles (TNPs) is described for enzyme-specific drug activation at tumor sites and simultaneous in vivo magnetic resonance imaging… Expand
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References

SHOWING 1-10 OF 50 REFERENCES
Development of a novel tumor-targeted vascular disrupting agent activated by membrane-type matrix metalloproteinases.
TLDR
The design and characterization of a novel VDA, ICT2588, that is nontoxic until activated specifically in the tumor by membrane-type 1 matrix metalloproteinase (MT1-MMP) is described, which achieves selective VDA targeting based on MT-M MP activation in the tumors microenvironment. Expand
Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases
TLDR
In vivo visualization of matrix metalloproteinase activities by MRI and fluorescence of dendrimeric nanoparticles coated with activatable cell penetrating peptides, labeled with Cy5, gadolinium, or both shows that uptake via this mechanism is comparable to that of other near infrared protease sensors, with the added advantage that the approach is translatable to MRI. Expand
Tumor-targeted drug delivery using MR-contrasted docetaxel - carboxymethylcellulose nanoparticles.
TLDR
It is affirmed that nanoparticle uptake is variable in tumor physiology, and that this efficacy-predictive parameter can be non-invasively estimated in real-time using a theranostic variant of Cellax. Expand
Therapeutic Nanoparticles for Drug Delivery in Cancer
TLDR
Multifunctional and multiplex nanoparticles are now being actively investigated and are on the horizon as the next generation of nanoparticles, facilitating personalized and tailored cancer treatment. Expand
Theranostic Applications of Nanomaterials in Cancer: Drug Delivery, Image-Guided Therapy, and Multifunctional Platforms
TLDR
Nanomedicine approaches in cancer have great potential for clinically translatable advances that can positively impact the overall diagnostic and therapeutic process and result in enhanced quality of life for cancer patients. Expand
Drug targeting to tumors: principles, pitfalls and (pre-) clinical progress.
TLDR
Intentions strongly suggest that besides making ever more nanomedicine formulations, future efforts should also address some of the conceptual drawbacks of drug targeting to tumors, and that strategies should be developed to overcome these shortcomings. Expand
Tumour endoproteases: the cutting edge of cancer drug delivery?
TLDR
The concept behind development of tumour‐endoprotease activated prodrugs is described and the various studies to date that have demonstrated the huge potential of this approach for improvement of cancer therapy are discussed. Expand
Enhanced permeability and retention (EPR) effect for anticancer nanomedicine drug targeting.
  • K. Greish
  • Medicine
  • Methods in molecular biology
  • 2010
TLDR
This selective high local concentration of nano-sized anticancer drugs in tumor tissues has proven superior in therapeutic effect with minimal side effects in both preclinical and clinical settings. Expand
Surface engineering of iron oxide nanoparticles for targeted cancer therapy.
TLDR
Once the critical design parameters have been optimized, these nanoparticles can serve as truly multifunctional theranostic agents that not only perform a therapeutic function but also provide instant clinical feedback, allowing the physician to adjust the treatment plan. Expand
Molecular imaging with theranostic nanoparticles.
TLDR
Diagnosis imaging and therapeutic uses of NPs are described and examples of five primary types of nanoparticles with concurrent diagnostic and therapeutic use are proposed. Expand
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